Evaluation of c-KIT protein expression in canine mammary tumors
نویسندگان
چکیده
Background c-KIT is a proto-oncogene that synthesizes a tyrosine kinase protein responsible for cell growth. Higher expression of c-KIT protein in women normal breasts correlates with differentiation status of normal breast epithelium, while loss of c-KIT expression is observed during progression or malignant transformation of mammary epithelium. In bitches the role of this tyrosine kinase receptor has not been established. The aim of this study was to identify c-KIT protein expression in canine breast tissue and compared results with c-KIT expression status in human breast tissue.
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